Considering that p27Kip1 was proposed as a prognostic biomarker for human melanoma [18] and that these tumors exhibited a pro-oxidant behavior due to an imbalance in the antioxidant system [36], [37] and to the melanin deregulation [38], human melanoma cells become an interesting model in order to broaden our previous results on H2O2 regulation of p27Kip1. Here, CDKN1B is linked to melanoma.