CDKN1B and metastatic melanoma: A recent study of tissue microarrays of human melanocytic lesions by Chen et al. also revealed that nuclear p27Kip1 expression was reduced in primary melanomas compared with dysplastic nevi and further reduced in metastatic melanoma, whereas the cytoplasmic p27Kip1 was increased in primary and metastatic melanomas compared with dysplastic nevi [18].