In a regression model that included all three biomarkers and baseline covariates used for adjustment (see Methods), higher levels of IL-6 (p<0.001), hsCRP (p = 0.003), and D-dimer (p = 0.002), older age (p<0.001), male gender (p = 0.04), higher CD4+ T cell count (p = 0.02), prior AIDS (p = 0.01), smoking (p = 0.002), prior CVD (p = 0.02), diabetes (p = 0.05), antihypertensive therapy (p<0.001), and the presence of major ECG abnormalities (p = 0.03) were associated with an increased risk of CVD. The gene discussed is IL6; the disease is AIDS.