MEK inhibition increased the sensitivity of 10 cancer cell lines to IFN (A375, DLD-1, DU145, HCT116, HT1080, HT29, HTB129, MDA468, MDAH and PA-1) (U0126 responsive cell lines), but had no effect in 3 cancer cell lines (LnCap, MCF7 and SW48) (U0126 non-responsive cell lines) (Fig. 2 and Fig. S1). This evidence concerns the gene MAP2K7 and cancer.