Rpusd2 is a possible analog of a human IBD candidate, PUS10; Spint1 regulates development; Vps18 is in the autophagy pathway; Dll4 encodes a Notch1 ligand; the Chac1 product links ER stress to apoptosis; a Slc30a4112 mutant causes lethal milk (zinc deficiency); the Cops2 protein is involved in the ubiquitin-proteasome COP9 signalosome that functions during general embryonic proliferation, T-cell development and T-cell antigen-stimulated proliferation [14], [42], [43], [44], [45], [46], [47]. The gene discussed is COPS8; the disease is inflammatory bowel disease.