The distal 125–133 mbp region includes a candidate human IBD gene, FERMT1, which encodes kindlin-1 localized at focal adhesions [10], [11], a spermine oxidase gene (Smox), an antioxidant transporter for ascorbate uptake (Slc23a2), several immunity genes (IL1a, IL1b and Sirpa), a major cell-cycle check-point gene (Bub1; marker SNP at 127.65 mbp) and a proliferative-cell-nuclear antigen gene (Pcna). Here, SMOX is linked to inflammatory bowel disease.