GJA1 and oculodentodigital dysplasia: The importance of Cx43 for bone homeostasis is demonstrated by the skeletal abnormalities present in mice with ablation of the Cx43 gene (Gja1) [4], and further underscored by the skeletal malformations described in patients with the autosomal dominant disorder oculodentodigital dysplasia, a disease linked to Gja1 mutations [5]–[7].