Comprehensive HIV care and treatment encompasses the clinical and social components necessary for the highest quality of care, including opportunistic infection prophylaxis, tuberculosis (TB) diagnosis and treatment, WHO clinical staging for HIV, highly active antiretroviral therapy (HAART), CD4 count monitoring, relevant laboratory tests (such as complete blood counts, creatinine, liver enzymes, etc.), adherence counseling, peer education, and access to support groups. The gene discussed is CD4; the disease is tuberculosis.