Comparative analysis of gene expression profiles of the Col4a3−/− mice, a CKD model of elevated circulating levels of FGF23, and two other models of FGF23 excess and normal renal function [31], [40], [42], [43], along with confirmation of FGF23 regulation of these transcripts in vivo and in vitro, identified novel genes not previously recognized to be regulated by FGF23 as well as confirmed the regulation of genes known to be regulated by FGF23 in the kidney. The gene discussed is FGF23; the disease is chronic kidney disease.