MUC1 and pancreatic intraductal papillary-mucinous neoplasm: In addition, we developed a novel method for detecting DNA methylation patterns called MSE, which enabled the detection of altered methylation in pancreatic juice and revealed the significantly different methylation patterns in the MUC1 promoter between intraductal papillary mucinous neoplasm and PDAC, indicating its potential diagnostic use [36].