In peripheral precocious puberty or GnRH-independent precocious puberty, boys develop secondary sexual characteristics from two conditions: secretion of androgens from the testes or adrenal glands, or rarely, secretion of human chorionic gonadotropin (hCG) or LH, which can stimulate Leydig cell production of testosterone [1]. This evidence concerns the gene PLOD1 and precocious puberty.