When conventional medicines were used, either as the sole intervention or in conjunction with CHM, adverse effects included vomiting, diarrhea, insomnia, rashes, blurred vision, edema, central obesity, increased ALT level, mild hepatic dysfunction, renal dysfunction, anemia, increased fasting blood glucose level, hypertension, hyperlipoidemia, and leucopenia occurred. Here, GPT is linked to anemia (phenotype).