The mechanisms of action of matrine against cancer cell proliferation and invasion are associated with epidermal growth factorvascular endothelial growth factor vascular endothelial growth factor receptor 1 Akt–nuclear factor-kappa B (EGF/VEGF—VEGFR1—Akt—NF-κB) signaling [36] (Table 2). The gene discussed is AKT1; the disease is cancer.