IFNA1 and systemic lupus erythematosus: These findings may be associated to the IFN-α pathway, since higher levels of IFN-α have been associated with increased levels of chemokines in SLE patients, suggesting an upregulation of this chemokine production according to Bauer et al. studies [28, 54]; likewise Quiong Fu has suggested the importance of type I IFN system in modulating chemokine expression, linking these two networks in the SLE pathogenesis [55].