When we grouped SLE patients based on the amount of anti-dsDNA antibodies in negative, low (<20 IU), moderate (20–50 IU), and high positive (>50 IU), we found, in pDC, an increase on ICOSL mRNA expression in the groups without anti-dsDNA antibodies and lower positive, when compared with moderate and high positive groups. The gene discussed is ICOSLG; the disease is systemic lupus erythematosus.