Concerning the tolerogenic function of monocytes and DCs subsets, a lower mRNA expression of ICOSL was observed in ASLE compared to HG in monocytes (Figure 2(b)) and, on the other hand, an increased ICOSL mRNA expression in mDCs from both SLE groups compared to HG, was found (Figure 4(a)). This evidence concerns the gene ICOSLG and systemic lupus erythematosus.