IL5 and acrodermatitis enteropathica: IL-5 is the predominant cytokine expressed by PBMCs in AE patients [5], and Th2-type IL-3, IL-5, and IL-10 were enhanced in severely ill AE patients [6–8] while E. multilocularis antigen-induced IFN-γ and spontaneous IL-12 production were decreased [9, 10].