Fecal screening for CRC with hypermethylated HIC1 gene detection compared with FOBT has shown promising results for this epigenetic marker in 26 patients with CRC, 13 with adenoma (≥1 cm), 9 with hyperplastic polyps, 9 with chronic inflammatory bowel disease, and 32 normal-controls. The gene discussed is HIC1; the disease is colorectal carcinoma.