IL10 and systemic lupus erythematosus: T2-MZP B cells also suppress other autoimmune diseases including antigen-induced arthritis (AIA) and lupus (Inoue et al., 2006; Carter et al., 2011), and Schistosoma mansoni infection generates IL-10 producing T2-MZP B cells with regulatory function (Amu et al., 2010).