Through theproduction of vascular endothelial growth factor A (VEGFA), they contribute to angiogenesis;by producing components of ECM, such as collagens and ECM degrading enzymes, such as MMPs,they contribute to stromal remodeling and to cell migration within the tumor(Ostrand-Rosenberg et al., 2012; Ruffell et al.,2012). This evidence concerns the gene VEGFA and neoplasm.