MLANA and infection: In previous work, our lab showed that the mLANA-null virus (73.Stop) displays dysregulated gene expression, characterized by hyper-expression of all temporal classes of viral genes at early time points post-infection of murine fibroblasts compared to the genetically-repaired marker rescue virus (73.MR), as measured by western blot [27] and RT-PCR (Paden and Speck unpublished observation).