MLANA and Splenomegaly: Somewhat surprisingly, we found that every mLANA mutant that was null in the TR transcription repression assay when introduced into MHV68, displayed limited splenomegaly, similar to the mLANA-null mutant (73.Stop) (Fig. 7A), and a reactivation phenotype comparable to the mLANA-null mutant (Fig. 7C) (i.e., these virus-infected cells displayed no detectable reactivation in the limiting dilution assay).