CFH and age-related macular degeneration: Recently, we demonstrated that the CFH Tyr402His polymorphism is a risk factor for developing AMD in Brazilian patients: an odds ratio of 1.36 for patients carrying only one 1277C allele (heterozygous CT; His/Tyr) and 4.63 for those carrying two 1277C alleles (homozygous CC; His/His) compared to the control group [26].