TNF and infection: Thanks to the influence of co-stimulating particles (CD 80), proinflammatory cytokines production (TNFa, IL1, 6, and 8) and anti-inflammatory cytokines (IL-10), adhesion proteins (ICAM 1), the influence on intracellular signalling pathways, and functions of T cells, their wider use is possible in the treatment of inflammatory conditions beyond the control of infection.