TNFRSF1B and acute respiratory distress syndrome: In contrast, blockade of TNFR2 significantly abrogated the protective effect of PGRN on the LPS-induced ALI as evidenced by elevated levels of total inflammatory cell count, proinflammatory cytokines, albumin and IgM in BAL fluid (Figures 6(a)–6(d), P < 0.05).