The percentages of CD4+CD25high and CD4+CD25highFoxP3+ cells were markedly higher in AD patients and SCORAD >60 than in those showing SCORAD <60 (p < 0.01), whereas both groups showed an increase in these subpopulations of cells as compared to controls (p < 0.001) (Table 1). The gene discussed is CD4; the disease is Alzheimer disease.