The aim of our paper was to study (1) the numbers of T-regulatory, CD3+CD4+and CD3+CD8+cells in the peripheral blood of AD patients depending on their disease activity (2) the some receptors on these cells and (3) the concentrations of IL-6, IL-10 and TGF-β in serum and production of these cytokines by CD4+ lymphocyte cultures. The gene discussed is CD4; the disease is Alzheimer disease.