CD4 and Alzheimer disease: The concentration of IL-10 and TGF-β in the serum and the concentration of IL-10 in CD4+ lymphocyte culture supernatant were decreased in AD patients as compared to controls (17.8 ± 3.0 vs. 19.9 ± 3.6 pg/ml, p < 0.05; 21.9 ± 4.5 vs. 27.9 ± 5.9 pg/ml, p < 0.001 and 840 ± 210 vs. 1,120 ± 340 pg/ml, p < 0.001, respectively).