HSPD1 and systemic lupus erythematosus: Our group previously exposed that the passive administration of wild-type M. leprae Hsp65 interfered with endogenous equilibrium by enhancing the entropy of the immunobiological system, as expressed by the early death of the (NZB×NZW)F1 experimental lupus mice [8] and aggravation of the ocular disease in experimental autoimmune Uveitis [16].