CXCL-8, CXCL-10, CCL-4, and CCL-11 levels were significantly higher (P < 0.05); IFN-gamma, TNF-alpha, IL-1alpha, IL-2, IL-6, IL-9, IL-15, GM-CSF, G-CSF, and CCL-2 levels were higher; IL-10, IL-12, and IL-13 levels were significantly lower (P < 0.05) in all CHC patients than in the controls. This evidence concerns the gene CXCL8 and cryohydrocytosis.