Apart from the diagnosis category considered, allergic and atopic manifestations (allergic rhinoconjunctivitis, nasal polyps and allergic chronic rhinosinusitis, asthma and bronchial hyperreactivity, urticarial skin lesions, and angioedema, hypereosinophilia and/or IgE elevation) were found in the record of only 10 patients (16.9%). This evidence concerns the gene IGHE and asthma.