Regarding the F1Fo-ATPsynthase endogenous regulator, IF1, its overexpression has been observed in many human carcinomas (including lung, colon, breast, and cervix carcinomas [10], Ehrlich ascites carcinoma [91], Zajdela hepatoma and Yoshida sarcoma [92]), but little is still known about the associated effects, and the few theories that have been put forward are highly controversial. The gene discussed is ATP5IF1; the disease is carcinoma.