Considering the important role played in the transcriptional processes by epigenetic mechanisms such as reversible or irreversible attachment of methyl groups to DNA catalyzed by DNMTs [37] and the recently evidenced interaction between PPARγ and DNMTs [14], we sought to evaluate if PPARγ and DNMTs show correspondent oscillation in pancreatic cancer, analyzing their time-related patterns of variation in synchronized pancreatic cancer cell lines. This evidence concerns the gene PPARG and pancreatic neoplasm.