In CFPAC-1 cells, derived from a pancreatic ductal adenocarcinoma liver metastasis of a patient with cystic fibrosis, a borderline significant rhythmicity with a 24 h period was found for the PPARG, DNMT1, and DNMT3B expression patterns, and the time-qualified profiles showed different shapes. Here, DNMT3B is linked to pancreatic ductal adenocarcinoma.