In the BxPC-3 cell line, mucin-producing cells derived from a human primary pancreatic adenocarcinoma, a borderline significant 24 h periodicity was evidenced for the PPARG, DNMT1, and DNMT3B expression patterns, and the time-qualified profiles of PPARG and DNMT3B, as well as the time qualified profiles of DNMT1 and DNMT3B, were opposing. Here, DNMT3B is linked to pancreatic adenocarcinoma.