Several in vitro studies using the human HCC cell line Huh7 have linked HCV (specifically viral protein NS5A) with increased transcriptional activity of PPARγ [90, 91] as well as increased recruitment of PPARγ coactivator-1α (PGC1α) to the peroxisome proliferator response element [91]. This evidence concerns the gene PPARG and hepatocellular carcinoma.