Any degree of hyperglycemia that the fetal tissues are exposed to, stimulates insulin secretion that can cause hypertrophy of insulin-sensitive tissues such as adipose tissue, skeletal and myocardial muscle, hepatic tissues and even islets of Langherhans in the pancreas; as a result, an accelerated fetal growth can be found and eventually macrosomia. This evidence concerns the gene INS and Hyperglycemia.