PROM1 and neoplasm: Moreover, when tumours were stratified according with CD133 expression, twenty-two (30.6%) out of 72 low expressor cases and 35 (54%) among the remaining 65 cases recurred during the period of follow-up and this difference was significant (p = 0.005) as also confirmed by the Kaplan-Meier curves of DFS which displayed a significant separation between the two groups of patients (p = 0.002 by log-rank test) (Figure3A).