Therefore, further studies are required to elucidate whether the different number of LRRs in YopM proteins of strain 8081 and WA-314: i) generally results in the interaction of the corresponding YopM proteins with different targets in the host, ii) especially causes distinct interaction or binding affinity with PRK2 and RSK1 and iii) has different consequences on the virulence of Y. enterocolitica in the mouse infection model. The gene discussed is PKN2; the disease is infection.