Although some investigators have observed that IL-6 infusion causes hepatic insulin resistance [41], this view is challenged by the induction of IL-6 in response to insulin-sensitizing exercise [42] and the ability of IL-6 infusion to increase glucose uptake, glucose metabolism, and fat oxidation in isolated tissues in vitro as well as in diabetic and non-diabetic humans [43]–[45]. Here, IL6 is linked to Insulin resistance.