CXCR4 and AIDS: Of note, children with R5X4 variants and the rs1801157 GA genotype had a ten-fold higher risk of developing late AIDS (OR = 10.00, 95% CI 1.30–78.00; p = 0.028) than children with the rs1801157 GG genotype and a R5X4 virus, thus supporting the premise of a primarily protective role of the rs1801157 GG genotype against viruses using CXCR4 coreceptor.