CXCL12 and AIDS: As opposed to that observed with the SDF1 SNP, the effect of the P1/P1 CCR5 haplotype was strongest in early AIDS (OR = 8.48, 95% CI 2.30–31.29; p = 0.001) when R5 viruses prevailed and lost after 84 months of age when R5X4 viral variants emerged in half of the studied children (Table 3).