These data indicate that miR-214 inhibits cell invasion by inhibiting EZH2 and CTNNB1. Corroborating with these results, expression of EZH2, CTNNB1 and CDH1 in a cohort of HCC patients studied in our laboratory previously by global gene expression profiling [4] also indicated that expression of both EZH2 and CTNNB1 are significantly up-regulated while CDH1 is down-regulated in human HCC compared to adjacent histologically normal liver tissues (Figure S5). Here, EZH2 is linked to hepatocellular carcinoma.