EZH2 and neoplasm: In summary, our data showed that miR-214 can provide tumor suppression function in hepatocarcinogenesis through modulating the expression of EZH2, CTNNB1 and CDH1. The reduction in the expression level of miR-214 during hepatocarcinogenesis resulted in the up-regulation of EZH2 and β-catenin and the down-regulation of E-cadherin.