Since EpCAM is a direct transcriptional target of the wnt-β-catenin canonical signaling pathway [26], [27], we have demonstrated that mR-214 can directly or indirectly modulate the expression of CTNNB1 through EZH2, we decided to investigate the effect of silencing miR-214 on the EpCAM+ HCC tumor cell population. This evidence concerns the gene EZH2 and hepatocellular carcinoma.