Consequently, we try to demonstrate here 3-azidoWA as well as TRAIL mediated inhibition of MMP-2 in cervical (data not shown) and prostate cancer cell line through induction of extracellular Par-4 which has been shown to induce extrinsic apoptotic pathway by FADD-caspase-8-caspase-3 activation [3]. This evidence concerns the gene CASP8 and prostate cancer.