The mutational status of various tumor suppressor genes such as retinoblastoma 1 (RB1), TP73, cyclin-dependent kinase inhibitor 2A (CDKN2A), breast cancer 1, early onset (BRCA1), BRCA2, TP53 and TP53BP2 (tumor protein p53 binding protein, 2) in the patient samples subjected to aCGH analysis was also examined (Table 3). The gene discussed is TP53BP2; the disease is cancer.