IFNL2 and colonic neoplasm: [21], [22], [46], [47]. From the perspective of biological function, many results have suggested anti-viral effects in several types of virus infection, including EMCV, HCV and CMV [21], [22], [46]–[48]. In addition to anti-viral effects, IL-28A also exhibits anti-proliferative and anti-tumor effects, in vitro and in vivo, in several types of tumor cells such as neuroendocrine tumor, colon cancer, murine melanoma, glioblastoma, and HaCaT cells [47], [49]–[52].