IL5 and tarsal-carpal coalition syndrome: At the first stage of the study, from these 10 genes we found 3 major cytokines, IL-5, IL-20, and IL-28A, which participate in migration, invasion, and MMP expression without affecting cell proliferation, indicating a coordinated program cluster to allow the progression of TCC as determined by the wound-healing migration, invasion assay, zymography, protein levels, and EMSA activity levels.