A 10-gene (KIT, SYNGR2, C21orf4, Hs.296031, Hs.24183, FAM13A1, C11orf8, KIAA1128, IMPACT, CDH1) and a 6-gene (KIT, LSM7, SYNGR2, C21orf4, Hs.296031, Hs.24183) assays have been proposed to have high diagnostic accuracy to distinguish thyroid nodules [6]. Here, TMEM50B is linked to thyroid nodule.