The metabolic syndrome (MetS) is a cluster of interrelated common clinical disorders, including obesity, hyperglycemia, insulin resistance, dyslipidemia, increased apolipoprotein B (apo B) levels, inflammation and hypertension, associated with an increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) [1]. The gene discussed is APOB; the disease is Obesity.