PTGS2 and endothelial dysfunction: Our results showed that systemic inflammation causes endothelial dysfunction and activates microglia in RVLM to induce COX-2-dependent neuroinflammation that leads to an increase in O2·- production, contributing to an increase in sympathetic neurogenic vasomotor tone and neurogenic hypertension possibly via downregulation of Kv4.3 potassium channel expression.