GRIN2A and neuroblastoma: In this study using retinoic acid differentiated SH-SY5Y neuroblastoma cells, a model known to be susceptible to NADPH oxidase-induced cell death [21], we sought to determine whether superoxide production from NADPH oxidase was involved in the activation of SFKs associated with PSD-95, thereby mediating the tyrosine phosphorylation of the NMDAR NR2A subunit.