Multivariate analysis including age, sex, histological subtype, tumour stage, and differentiation identified the CRP-value as a continuous metric variable as an independent prognosticator for cancer-specific (HR 1.007, 95% CI: 1.004-1.009; p < 0.001, Cox regression) as well as overall survival (HR 1.006, 95% CI: 1.004-1.008; p < 0.001, Cox regression) in patients with RCC. This evidence concerns the gene CRP and cancer.