Body fat accumulation and hyperlipidemia enhance insulin resistance (IR), by increasing free fatty acid in portal blood vessels, impairing insulin signaling on one hand, and by inhibiting key signaling proteins, indicating disturbances in glucose and lipid metabolism (as revealed by significant positive correlation of LDL with FBG in this study), and lead to cortisol secretion on the other hand [25]. This evidence concerns the gene INS and Insulin resistance.