In the univariate analysis, abnormal ABI was found to be significantly associated with increased age, a history of DM, hypertension, coronary artery disease, and cerebrovascular disease, decreased diastolic blood pressure, increased pulse pressure, decreased albumin, increased fasting glucose, decreased hematocrit, decreased eGFR, proteinuria and increased LVMI. The gene discussed is ALB; the disease is cerebrovascular disorder.