The precise mechanism by which the immune system is activated in its response to the TSHR antigen in Graves’ disease remains unclear but it is now known that the various pathogenic auto antibodies to the TSHR activate or deactivate the receptor by binding to contiguous, non-contiguous or to both types of epitopes on the extracellular region of the receptor [30], [31], [32]. This evidence concerns the gene TSHR and Graves disease.