To investigate whether RBMS3 has tumor suppressive ability, RBMS3 was stably transfected into 2 NPC cell lines (SUNE1 and CNE2), and 4 clones (SUNE1-R4, SUNE1-R5, CNE2-R1 and CNE2-R2) were selected for functional studies. The gene discussed is RBMS3; the disease is nasopharyngeal carcinoma.