To exclude that some of the hypointense signals detected by MRI were background signals due to inflammation, iron accumulation due to hemorrhage or tumor growth, we included, in addition to controls with irrelevant antibodies coupled to the mGNPs (anti-hp53, anti-mouse CD3ε) or PBS injection, appropriate controls for each animal, namely the MRI data of the same animal prior to Nilo2-mGNP injection in the contralateral hemisphere (i.e. d+12 in Figure 3). This evidence concerns the gene CD3E and neoplasm.