Her-2 amplified specimen (Figure 1Ai) showed weak staining of AnxA2 (0–1+, 0–10% cells showed very faint staining) while Her-2 null/basal breast cancer specimen demonstrated strong membrane expression of AnxA2 (Figure 1Aii, >3+, >30% cells with strong membranous staining). Here, ANXA2 is linked to breast cancer.