MAP3K5 and myeloid leukemia: A high NO flux >1 μM steady state NO produced by LPS-induced Toll-like receptor activation mediated nitrosation and down regulation of apoptosis signal regulating kinase-1 (ASK1) and subsequent suppression of caspase-3 activity in LPS treated myeloid leukemia cells [49]; this high level of NO involves formation of RNS [42].