Studies have correlated high TIMP-1 with breast and colorectal tumor resistance to hormone therapy, cyclophosphamide/methotrexate/5-fluorouracil, cyclophosphamide/epirubicin/5-fluorouracil, cyclophosphamide/adriamycin/5- fluorouracil, or single agent adriamycin [12], [13]. Here, TIMP1 is linked to colorectal neoplasm.