TP53 and cancer: In addition to the Akt signaling pattern shown herein, threshold levels of NO can promote tumorigenesis by targeting other key mediators of cancer progression and angiogenesis including phosphorylation of p53 (1000 nM steady state), stabilization of HIF-1alpha (300–800 nM steady state), protein translational machinery and proliferation signaling pathways (100 nM Steady state) [29], [34], [43].