The male F3 vinclozolin-lineage descendants differed from vehicle-lineage counterparts in how adolescent stress affected subsequent performance on tests of anxiety/stress, and that these same animals differed in expression of genes in hippocampus and amygdala, including Mc3r and Mc4r, similar to results in BPA-exposed F1 rats in the current study. This evidence concerns the gene MC4R and Anxiety.