Results showed that the SRC method is able to better locate genes significant for the diagnosis of osteoporosis patients than those from a single data set. In addition, our proposed SRC method gives better diagnosis results when compared with the T-test and Fisher-exact test. In particular, we identified two new osteoporosis risk genes (e.g., ‘DICER1’, ‘PTMA’) through joint data analysis. This evidence concerns the gene DICER1 and osteoporosis.