When compared with previously reported osteoporosis susceptible genes, the SRC based gene shaving method not only identified genes that were previously reported [19], such as ‘THSD4’, ‘CRHR1’, ‘HSD11B1’, ‘THSD7A’, ‘BMPR1B’ ‘ADCY10’, ‘PRL’, ‘CA8’, ‘ESRRA’, ‘CALM1’, ‘CALM1’, ‘SPARC’, ‘LRP1’, but also new susceptive genes (‘DICER1’, ‘PTMA’ et. This evidence concerns the gene ADCY10 and osteoporosis.