When compared with previously reported osteoporosis susceptible genes, the SRC based gene shaving method not only identified genes that were previously reported [19], such as ‘THSD4’, ‘CRHR1’, ‘HSD11B1’, ‘THSD7A’, ‘BMPR1B’ ‘ADCY10’, ‘PRL’, ‘CA8’, ‘ESRRA’, ‘CALM1’, ‘CALM1’, ‘SPARC’, ‘LRP1’, but also new susceptive genes (‘DICER1’, ‘PTMA’ et. The gene discussed is ESRRA; the disease is osteoporosis.